- A systematic review and meta-analysis suggests that continued smoking after radiotherapy (RT) is associated with recurrence and poor survival in patients with head and neck cancer (HNC).
Why this matters
- Smoking cessation should be strongly encouraged after HNC diagnosis .
- Continued smoking was associated with increased risk of mortality (risk ratio [RR], 1.85; P<.0001 and locoregional failure compared with smoking cessation.>
- Qualitative synthesis suggested that continued smoking is associated with an increase in late toxicities but not acute toxicities.
- 24 studies (6332 patients) with squamous cell carcinomas of the oral cavity, larynx, or pharynx were included in the meta-analysis.
- Funding: None.
- Meta-analysis mostly included retrospective studies.
- Heterogeneity between included studies.