HNC: continued smoking post-RT tied to recurrence, poor survival

  • Radiother Oncol

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A systematic review and meta-analysis suggests that continued smoking after radiotherapy (RT) is associated with recurrence and poor survival in patients with head and neck cancer (HNC).

Why this matters

  • Smoking cessation should be strongly encouraged after HNC diagnosis .

Key results

  • Continued smoking was associated with increased risk of mortality (risk ratio [RR], 1.85; P<.0001 and locoregional failure compared with smoking cessation.>
  • Qualitative synthesis suggested that continued smoking is associated with an increase in late toxicities but not acute toxicities.

Study design

  • 24 studies (6332 patients) with squamous cell carcinomas of the oral cavity, larynx, or pharynx were included in the meta-analysis.
  • Funding: None.

Limitations

  • Meta-analysis mostly included retrospective studies.
  • Heterogeneity between included studies.