- A prospective, observational study suggests that current smoking status at time of diagnosis is associated with increased all-cause mortality in patients with head and neck cancer (HNC).
Why this matters
- Despite a well-known association with HNC risk, the prognostic role of smoking status at diagnosis was less clear.
- Current smokers (HR, 1.71; P=.001) and former smokers (HR, 1.4; P=.001) had increased all-cause mortality risk compared with never smokers.
- In subgroup analysis, current smoking was associated with increased all-cause mortality risk in patients with oropharyngeal (HR, 1.8; P=.008) and laryngeal cancer (HR, 2.3; P=.011).
- Hazardous/harmful alcohol drinking (HR, 1.1; P=.314) was not significantly associated with mortality.
- HPV status did not significantly modify the association between smoking and mortality (P=.263).
- 1393 patients with HNC from the prospective Head and Neck 5000 study were analyzed for factors associated with all-cause mortality.
- 403 patients had oral cavity cancer, 660 had oropharyngeal cancer, and 330 had laryngeal cancer.
- Funding: National Institute for Health Research (UK).
- Smoking and alcohol intake were self-reported.
- Observational study design.