- Pathological complete remission (pCR) after preoperative radiotherapy/chemoradiotherapy (RT/CRT) is associated with improved survival outcomes among patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
Why this matters
- Identification of prognostic factors can help guide patient management.
- 34.7% of patients experienced pCR.
- Compared with lack of pCR, pCR was associated with better:
- Local control: 93.2% vs 67.7% (P=.007).
- OS: 83.3% vs 39.7% (P=.0006).
- PFS: 76.1% vs 44.0% (P=.003).
- Distant metastasis-free survival: 90.4% vs 56.3% (P=.005).
- pCR remained associated with improved local control (HR, 54.839; P=.002) and OS (HR, 11.71; P=.000) in multivariate analysis.
- Included 72 patients with LA-HNSCC who did not initially respond to preoperative RT/CRT and subsequently underwent resection of the primary lesion with or without neck dissection.
- Their data were analyzed for associations between pathological tumor response and prognosis.
- Funding: National Key R&D Program of China.
- Small patient numbers.