How much weight reduction is required to achieve T2D remission?

  • Dambha-Miller H & al.
  • Diabet Med
  • 3 Sep 2019

  • International Clinical Digest
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Takeaway

  • Weight loss of ≥10% within a few years of type 2 diabetes (T2D) diagnosis is strongly associated with T2D remission at 5 years.

Why this matters

  • Previous studies have shown that T2D remission is possible with intensive caloric restriction/lifestyle intervention, but few have addressed less-intensive interventions.

Study design

  • Prospective cohort study of 730 people ages 40-69 years newly diagnosed with T2D.
  • Funding: Wellcome Trust; Medical Research Council; UK National Institute for Health Research.

Key results

  • Diabetes remission (HbA1c
  • Those achieving remission were more often male, smokers, and with full-time education beyond age 16 years.
  • Compared with no weight change and after adjustments, people who lost ≥10% of body weight in first year after diagnosis were significantly more likely to achieve T2D remission at 5 years (risk ratio, 1.77; P<.01>
  • Remission likelihood was nonsignificantly increased for 5%-10% weight loss (risk ratio, 1.24; P=.17).
  • In subsequent 1-5 years, ≥10% weight loss was also associated with remission (risk ratio, 2.43; P<.01>
  • No consistent patterns of associations between unit changes in health behaviors (energy intake, physical activity, etc.) and T2D remission.

Limitations

  • Primarily white population.