- Weight loss of ≥10% within a few years of type 2 diabetes (T2D) diagnosis is strongly associated with T2D remission at 5 years.
Why this matters
- Previous studies have shown that T2D remission is possible with intensive caloric restriction/lifestyle intervention, but few have addressed less-intensive interventions.
- Prospective cohort study of 730 people ages 40-69 years newly diagnosed with T2D.
- Funding: Wellcome Trust; Medical Research Council; UK National Institute for Health Research.
- Diabetes remission (HbA1c
- Those achieving remission were more often male, smokers, and with full-time education beyond age 16 years.
- Compared with no weight change and after adjustments, people who lost ≥10% of body weight in first year after diagnosis were significantly more likely to achieve T2D remission at 5 years (risk ratio, 1.77; P<.01>
- Remission likelihood was nonsignificantly increased for 5%-10% weight loss (risk ratio, 1.24; P=.17).
- In subsequent 1-5 years, ≥10% weight loss was also associated with remission (risk ratio, 2.43; P<.01>
- No consistent patterns of associations between unit changes in health behaviors (energy intake, physical activity, etc.) and T2D remission.
- Primarily white population.