- In a systematic review and meta-analysis, F-18 fluorocholine (FCH) positron emission tomography (PET)/CT had pooled sensitivity of 90% and pooled specificity of 94% for localization of hyperfunctioning parathyroid glands in patients with hyperparathyroidism.
Why this matters
- This meta-analysis supports the utility of F-18 FCH PET/CT for patients with hyperparathyroidism.
- Pooled sensitivity was 90% without heterogeneity (I2, 7.1; P=.375) and pooled specificity was 94% with heterogeneity (I2, 79.8; P=.000).
- The overall positive likelihood ratio was 5.3 (95% CI, 1.2-24.3) and the overall negative likelihood ratio was 0.15 (95% CI, 0.08-0.29).
- The pooled diagnostic OR was 38 (95% CI, 8-174).
- The area under the curve was 0.9492 (standard error, 0.0215) in receiver operating characteristic analysis.
- 8 studies were subjected to meta-analysis to determine the diagnostic performance of F-18 FCH PET/CT for localization of hyperfunctioning parathyroid glands.
- Funding: None disclosed.
- Heterogeneity between studies.