HPV vaccine: provider recommendations drive uptake among adolescent males

  • Lu PJ & al.
  • J Pediatr
  • 15 Nov 2018

  • curated by Liz Scherer
  • Clinical Essentials
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  • While HPV vaccination coverage among adolescent males has increased since 2011, provider recommendations are significantly associated with vaccination, even after controlling for various demographic and access-to-care factors.

Why this matters

  • Emphasize HPV-related cancer prevention among adolescent patients/caregivers.
  • Use routine visits to review vaccination history, endorse HPV vaccine, and encourage same-day vaccinations/catch-up vaccinations.
  • Consider standing orders, provider reminders combined with health system interventions.

Key results

  • 9712 male adolescents.
  • HPV vaccination coverage increased significantly from 8.3% (2011) to 57.3% (2016; test for trend P<.05>
  • Prevalence of provider recommendations increased significantly from 14.2% (2011) to 65.5% (2016; test for trend P<.05 style="list-style-type:circle;">
  • Among patients receiving provider recommendation, HPV vaccination increased from 35.4% (2011) to 68.8% (2016; test for trend P<.05>
  • Multivariate analysis: characteristics associated with higher HPV vaccination likelihood included: 1) provider recommendation, 2) age 16-17 years, 3) black or Hispanic race/ethnicity, 4) Medicaid insurance, 5) >2 physician contact over past year, 6) urban/suburban residence.
  • Study design

    • 2011-2016 National Immunization Survey-Teen (NIS-Teen) data analysis evaluating trends and factors associated with HPV vaccination, provider recommendations among male adolescents, 13-17 years.
    • Funding: CDC.


    • Low overall household response rates.
    • Nonresponder biases.
    • Underestimates, provider recall bias.
    • Trends across 2011-2016 subject to bias.

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