- Use of human insulin is associated with a dose- and duration-dependent increased risk for lung cancer in patients with type 2 diabetes (T2D).
Why this matters
- Previous studies on the association between insulin use and lung cancer risk yielded inconsistent results.
- 1,007,617 people with T2D enrolled in Taiwan’s National Health Insurance.
- Funding: Ministry of Science and Technology of Taiwan.
- 156,720 had used human insulin (ever-users) and 850,897 had not (never-users).
- Ever-users had a higher rate of incident lung cancer (1.92% vs 1.61%; 424.45 vs 313.60 per 100,000 person-years).
- Lung cancer risk was significantly higher among ever-users than never-users (aHR, 1.545; 95% CI, 1.478-1.614).
- Risk was exacerbated among ever-users with COPD vs non-COPD never-users (HR, 1.891; 95% CI, 1.767-2.024).
- Lung cancer risk increased with increasing dosage of human insulin (
- Lung cancer incidence increased with increasing age among ever-users and was highest in age ≥70 years vs
- All-Taiwanese cohort.
- No data on smoking history.