- Preprocedural hyperglycemia (PH) is significantly associated with the risk for contrast-induced nephropathy (CIN) following coronary angiography (CAG), including in patients without diabetes.
Why this matters
- Previous studies on this relationship have been underpowered.
- Meta-analysis of 8 studies from the United States, Europe, and Asia, including 10,991 patients undergoing CAG.
- Funding: None.
- Overall, PH was significantly associated with increased CIN risk (pooled ORs) when PH was defined as:
- ≥140 mg/dL: 1.71 (P<.001 or>
- ≥200 mg/dL: 2.07 (P<.001>
- Pooled OR: 2.56 (P<.001>
- ≥140 mg/dL: 1.76 (P<.001 or>
- ≥200 mg/dL: 2.83 (P<.001>
- Causal relationship unproven.
- Insufficient data for subgroup analysis on populations with diabetes or without baseline chronic kidney disease.
- Potential confounding.