Hypertension and risk for sudden cardiac death

  • Pan H & al.
  • Eur J Epidemiol
  • 24 Dec 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • This meta-analysis found an increased risk for sudden cardiac death (SCD) with hypertension diagnosis and increasing systolic blood pressure (SBP).
  • No association was observed between diastolic BP (DBP) and SCD.

Why this matters

  • Elevated BP and hypertension have been associated with increased risk of SCD, but the findings have not been consistent.

Study design

  • Meta-analysis included 18 studies after a search across PubMed and Embase databases.
  • Funding: None disclosed.

Key results

  • Prevalent hypertension (relative risk [RR], 2.10; 95% CI, 1.71-2.58; I2=56.7%) and each 20-mmHg increase in SBP (RR, 1.28; 95% CI, 1.19-1.38) were associated with an increased risk for SCD.
  • No association was observed between each 10-mmHg increase in DBP and risk for SCD (RR, 1.09; 95% CI, 0.83-1.44; I2=83.4%).
  • In sensitivity analysis:
    • The risk for SCD was higher with prevalent hypertension (RR, 2.00; 95% CI, 1.52-2.63; I2=88.0%) and each 20-mmHg increase in SBP (RR, 1.25; 95% CI, 1.15-1.36; I2=63.9%).
    • No association was observed between each 10-mmHg increase in DBP and risk for SCD (RR, 1.08; 95% CI, 0.92-1.27; I2=77.4%).

Limitations

  • Heterogeneity among studies.
  • Risk for potential confounding.