- The risk for later cardiovascular diseases, including coronary artery disease, heart failure, aortic stenosis, and mitral regurgitation was higher in women with hypertension during pregnancy.
- History of hypertensive disorders of pregnancy (HDP) was associated with persistently increased arterial stiffness.
Why this matters
- Findings warrant dedicated study in terms of strategy to mitigate long-term cardiovascular risk in women with prior HDP.
- Study of 220,024 women (aged 40-69 years) who reported ≥1 prior live birth using data from the UK Biobank.
- Incidence of diverse cardiovascular conditions evaluated among parous women with and without prior hypertensive disorders of pregnancy
- Funding: None disclosed.
- A total of 2808 (1.3%) women had prior HDP.
- After adjustment, prior HDP was associated with higher arterial stiffness index (ASI) by 0.32 m/s (95% CI, 0.13-0.51 m/s; P=.001).
- Women with HDP vs those without HDP had a higher risk for time-to-first incident cardiovascular diagnosis (HR, 1.3; 95% CI, 1.04-1.60; P=.02); age-adjusted disease diagnoses occurred in 7.0 vs 5.3 per 1000 women-years (P=.001).
- Prior HDP was associated with a higher incidence of:
- coronary artery disease [CAD] (HR, 1.8; 95% CI, 1.3-2.6; P<.001>
- heart failure (HR, 1.7; 95% CI, 1.04-2.60; P=.03),
- aortic stenosis (HR, 2.9; 95% CI, 1.5-5.4; P<.001 and>
- mitral regurgitation (HR, 5.0; 95% CI, 1.5-17.1; P=.01).
- Self-reported data.
- Risk of bias.