Hypertension: hypothyroidism tied to excess risk for ICH

  • RuiZhang H & al.
  • World Neurosurg
  • 14 Aug 2019

  • International Clinical Digest
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Takeaway

  • In patients with hypertension, hypothyroidism is associated with increased risk for hypertensive intracerebral hemorrhage (ICH), according to a case-control study.

Why this matters

  • Identifying risk factors can assist prevention and treatment of hypertensive cerebral hemorrhage.

Key results

  • Hypothyroidism was present in 23.4% of patients with hypertensive ICH and 14.3% of matched control individuals with hypertension.
  • Hypothyroidism was associated with increased risk for hypertensive ICH in multivariate analysis (OR, 2.29 [P=.001]; OR, 1.92 [P=.016] in separate propensity score matching analysis).
  • Male sex (OR, 2.11; P<.05 and diabetes p=".037)" were also associated with increased risk for hypertensive ich whereas hyperlipidemia appeared to exert a protective effect>

Study design

  • 462 patients, 231 with hypertensive ICH and 231 with hypertension, were analyzed for the prevalence of hypothyroidism.
  • 179 patients with hypertensive ICH and 179 control individuals were included in the propensity-matched analysis.
  • Funding: None disclosed.

Limitations

  • Retrospective study design.