- 72% of people with frailty have hypertension, and 14% of people with hypertension have frailty, according to this meta-analysis.
Why this matters
- Given the possible effects of frailty on cost-benefit balance in hypertensive treatment, frailty may need to be considered in decision-making, say these authors.
- Among people with frailty, pooled hypertensive prevalence was 72% (95% CI, 66%-79%).
- Among people with hypertension, pooled frailty prevalence was 14% (95% CI, 12%-17%).
- Pooled OR for association between frailty and hypertension: 1.33 (95% CI, 0.94-1.89).
- Studies of an association have yielded mixed, “very different” results, according to a systematic review accompanying the meta-analysis (e.g., of 23 cross-sectional studies, 13 found an association, 10 did not).
- Publication bias not evident; low-moderate risk for methodological bias among studies.
- Systematic review, meta-analysis of 32 published articles (n=56-144,403; mean age range, 60-81 years).
- Funding: European Commission, 3rd Health Programme.
- Variable definitions of frailty, hypertension.