Hypertension is a common companion of frailty

  • Vetrano DL & al.
  • BMJ Open
  • 28 Dec 2018

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • 72% of people with frailty have hypertension, and 14% of people with hypertension have frailty, according to this meta-analysis.

Why this matters

  • Given the possible effects of frailty on cost-benefit balance in hypertensive treatment, frailty may need to be considered in decision-making, say these authors.

Key results

  • Among people with frailty, pooled hypertensive prevalence was 72% (95% CI, 66%-79%).
  • Among people with hypertension, pooled frailty prevalence was 14% (95% CI, 12%-17%).
  • Pooled OR for association between frailty and hypertension: 1.33 (95% CI, 0.94-1.89).
  • Studies of an association have yielded mixed, “very different” results, according to a systematic review accompanying the meta-analysis (e.g., of 23 cross-sectional studies, 13 found an association, 10 did not).
  • Publication bias not evident; low-moderate risk for methodological bias among studies.

Study design

  • Systematic review, meta-analysis of 32 published articles (n=56-144,403; mean age range, 60-81 years).
  • Funding: European Commission, 3rd Health Programme.

Limitations

  • Variable definitions of frailty, hypertension.