Hypertensive disorders of pregnancy: can we prevent it?

Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Combined calcium and aspirin are the most likely candidates for prevention of hypertensive disorders of pregnancy (HDP).

Study design

  • Review and meta-analysis of interventions to prevent HDP.
  • 25 studies were eligible to be included in the final analysis.

Key results

  • 14 different drug and dietary interventions were examined in the 25 studies.
  • Calcium and aspirin are the best potential candidates for the prevention of HDP with polypill.
  • Polypill therapy is preferred for ease of use.
  • In addition to calcium and aspirin, vitamin D and B12 are also possible candidates.

Limitations

  • Review and meta-analysis.

Why this matters

  • HDP are a major cause of maternal and neonatal morbidity and mortality worldwide and there is much interest in developing strategies for HDP prevention.
  • Candidates for this treatment would be women at risk for preeclampsia, such as women with preexisting hypertension.
  • Effectiveness of calcium and aspirin still needs to be established.