Hypertensive disorders of pregnancy: can we prevent it?

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  • Combined calcium and aspirin are the most likely candidates for prevention of hypertensive disorders of pregnancy (HDP).

Study design

  • Review and meta-analysis of interventions to prevent HDP.
  • 25 studies were eligible to be included in the final analysis.

Key results

  • 14 different drug and dietary interventions were examined in the 25 studies.
  • Calcium and aspirin are the best potential candidates for the prevention of HDP with polypill.
  • Polypill therapy is preferred for ease of use.
  • In addition to calcium and aspirin, vitamin D and B12 are also possible candidates.


  • Review and meta-analysis.

Why this matters

  • HDP are a major cause of maternal and neonatal morbidity and mortality worldwide and there is much interest in developing strategies for HDP prevention.
  • Candidates for this treatment would be women at risk for preeclampsia, such as women with preexisting hypertension.
  • Effectiveness of calcium and aspirin still needs to be established.