- Combined calcium and aspirin are the most likely candidates for prevention of hypertensive disorders of pregnancy (HDP).
- Review and meta-analysis of interventions to prevent HDP.
- 25 studies were eligible to be included in the final analysis.
- 14 different drug and dietary interventions were examined in the 25 studies.
- Calcium and aspirin are the best potential candidates for the prevention of HDP with polypill.
- Polypill therapy is preferred for ease of use.
- In addition to calcium and aspirin, vitamin D and B12 are also possible candidates.
- Review and meta-analysis.
Why this matters
- HDP are a major cause of maternal and neonatal morbidity and mortality worldwide and there is much interest in developing strategies for HDP prevention.
- Candidates for this treatment would be women at risk for preeclampsia, such as women with preexisting hypertension.
- Effectiveness of calcium and aspirin still needs to be established.