- Women with hyperthyroidism have lower odds of live birth with assisted reproduction technology (ART), whereas those with hypothyroidism have higher odds of offspring with congenital malformations.
Why this matters
- Thyroid disorders have been linked to infertility and poor reproductive outcomes, but the effect on ART outcomes is unclear.
- Hyperthyroidism was associated with reduced odds of:
- Biochemical pregnancy (aOR, 0.80; 95% CI, 0.69-0.93).
- Clinical pregnancy (aOR, 0.74; 95% CI, 0.58-0.96).
- Live birth (aOR, 0.86; 95% CI, 0.76-0.98).
- Hypothyroidism was not significantly associated with odds of biochemical pregnancy (aOR, 1.05; 95% CI, 0.97-1.14), clinical pregnancy (aOR, 0.95; 95% CI, 0.81-1.12), or live birth (aOR, 1.03; 95% CI, 0.94-1.12).
- Hypothyroidism was associated with increased odds of congenital malformation in offspring (aOR, 1.46; 95% CI, 1.07-2.00).
- Nationwide study of 67,627 women who underwent ART treatments, including 2101 with thyroid disorders.
- Funding: Beckett Foundation; Odense University Hospital.
- Observational design.
- Databases failed to capture biomarker levels, thyroid disorder etiology, and disease activity/treatment before ART.