Hyperthyroidism tied to lower chance of live birth with assisted reproduction

  • Jølving LR & al.
  • Clin Epidemiol
  • 1 Jan 2019

  • International Clinical Digest
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Takeaway

  • Women with hyperthyroidism have lower odds of live birth with assisted reproduction technology (ART), whereas those with hypothyroidism have higher odds of offspring with congenital malformations.

Why this matters

  • Thyroid disorders have been linked to infertility and poor reproductive outcomes, but the effect on ART outcomes is unclear.

Key results

  • Hyperthyroidism was associated with reduced odds of:
    • Biochemical pregnancy (aOR, 0.80; 95% CI, 0.69-0.93).
    • Clinical pregnancy (aOR, 0.74; 95% CI, 0.58-0.96).
    • Live birth (aOR, 0.86; 95% CI, 0.76-0.98).
  • Hypothyroidism was not significantly associated with odds of biochemical pregnancy (aOR, 1.05; 95% CI, 0.97-1.14), clinical pregnancy (aOR, 0.95; 95% CI, 0.81-1.12), or live birth (aOR, 1.03; 95% CI, 0.94-1.12).
  • Hypothyroidism was associated with increased odds of congenital malformation in offspring (aOR, 1.46; 95% CI, 1.07-2.00).

Study design

  • Nationwide study of 67,627 women who underwent ART treatments, including 2101 with thyroid disorders.
  • Funding: Beckett Foundation; Odense University Hospital.

Limitations

  • Observational design.
  • Databases failed to capture biomarker levels, thyroid disorder etiology, and disease activity/treatment before ART.