- High-density lipoprotein (HDL) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) are altered in men with hypogonadism.
Why this matters
- Disruptions in HDL function may help explain why patients with hypogonadism are at increased risk for CV events.
- Patients with hypogonadism and control subjects had similar lipid profiles.
- Patients with hypogonadism had 16.2% reduced total CEC (P<.0001 style="list-style-type:circle;">
- 19.6% lower levels HDL ATP binding cassette transporter A1 (P=.0012).
- 40.9% lower levels of ATP binding cassette transporter G1 (P<.0001>
- 12.9% lower levels of aqueous diffusion-mediated CEC (P=.0128).
- 20 hypogonadal men and 17 age- and BMI-matched control participants were analyzed for HDL functional capacity.
- Funding: IRCCS Istituto Auxologico Italiano; Fondazione Cariplo; Intramural Grant Piano Sostegno alla Ricerca; Fondazione Carlo Sirtori.
- Small patient sample size.
- HDL structure/composition not tested.