Takeaway
- This meta-analysis suggests that hyponatraemia is independently associated with increased short- and long-term all-cause mortality risk in patients after stroke.
Why this matters
- Findings highlight the importance of monitoring serum sodium levels, which may help physicians identify high-risk patients and guide in-hospital management.
Study design
- 12 studies involving 21,973 participants met eligibility criteria after a search on PubMed, EMBASE, the Cochrane Library and Web of Science.
- Funding: None disclosed.
Key results
- Incidence of hyponatraemia in stroke was 13.4% and on admission in stroke was 12.2%.
- Hyponatraemia was associated with a higher risk for all-cause mortality:
- in short-term (relative risk [RR], 1.61 [95% CI, 1.33-1.96]; HR, 1.78 [95% CI, 1.19-2.75]);
- in long-term follow-up (RR, 1.77 [95% CI, 1.27-2.47]; HR, 2.23 [95% CI, 1.30-3.82]).
- In subgroup analysis, hyponatraemia was associated with increased risk for all-cause mortality:
- in short-term (RR, 1.44; 95% CI, 1.23-1.70) and long-term follow-up (RR, 1.20; 95% CI, 1.14-1.26).
Limitations
- Heterogeneity among included studies.
References
References