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Clinical Summary

Hyponatraemia independently linked to all-cause mortality risk in patients with stroke

 Takeaway

  • This meta-analysis suggests that hyponatraemia is independently associated with increased short- and long-term all-cause mortality risk in patients after stroke.

Why this matters

  • Findings highlight the importance of monitoring serum sodium levels, which may help physicians identify high-risk patients and guide in-hospital management.

Study design

  • 12 studies involving 21,973 participants met eligibility criteria after a search on PubMed, EMBASE, the Cochrane Library and Web of Science.
  • Funding: None disclosed.

Key results

  • Incidence of hyponatraemia in stroke was 13.4% and on admission in stroke was 12.2%.
  • Hyponatraemia was associated with a higher risk for all-cause mortality:
    • in short-term (relative risk [RR], 1.61 [95% CI, 1.33-1.96]; HR, 1.78 [95% CI, 1.19-2.75]);
    • in long-term follow-up (RR, 1.77 [95% CI, 1.27-2.47]; HR, 2.23 [95% CI, 1.30-3.82]).
  • In subgroup analysis, hyponatraemia was associated with increased risk for all-cause mortality:
    • in short-term (RR, 1.44; 95% CI, 1.23-1.70) and long-term follow-up (RR, 1.20; 95% CI, 1.14-1.26).

Limitations

  • Heterogeneity among included studies.

References


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