- A retrospective study suggests that the neutrophil-to-lymphocyte ratio (NLR) is associated with treatment response and survival of patients with hypopharyngeal cancer (HPC) treated with definitive chemoradiotherapy (CRT).
Why this matters
- Predicting treatment response and outcome can help guide patient management.
- NLR ≥4 was associated with moderate-to-severe anemia (P=.02), advanced T classification (P=.01), and advanced stage (P=.02).
- 52.5% of patients achieved complete response.
- Median PFS was 22.5 months and median OS was 31.3 months.
- NLR ≥4 was associated with poor treatment response (HR, 2.42; P=.03).
- NLR ≥4 was associated with reduced PFS (HR, 1.71; P=.046) and OS (HR, 1.99; P=.01) in multivariate analysis.
- 120 patients with nonmetastatic HPC treated with definitive CRT were analyzed for NLR and associations with response and survival.
- Funding: National Cheng Kung University Hospital.
- Retrospective study from a single center.