Hypopharyngeal cancer: high NLR predicts poor CRT outcomes in Taiwanese study

  • Kuo C & al.
  • Sci Rep
  • 7 Feb 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A retrospective study suggests that the neutrophil-to-lymphocyte ratio (NLR) is associated with treatment response and survival of patients with hypopharyngeal cancer (HPC) treated with definitive chemoradiotherapy (CRT).

Why this matters

  • Predicting treatment response and outcome can help guide patient management.

Key results

  • NLR ≥4 was associated with moderate-to-severe anemia (P=.02), advanced T classification (P=.01), and advanced stage (P=.02).
  • 52.5% of patients achieved complete response.
  • Median PFS was 22.5 months and median OS was 31.3 months.
  • NLR ≥4 was associated with poor treatment response (HR, 2.42; P=.03).
  • NLR ≥4 was associated with reduced PFS (HR, 1.71; P=.046) and OS (HR, 1.99; P=.01) in multivariate analysis.

Study design

  • 120 patients with nonmetastatic HPC treated with definitive CRT were analyzed for NLR and associations with response and survival.
  • Funding: National Cheng Kung University Hospital.

Limitations

  • Retrospective study from a single center.