- A nomogram based on 5 independent factors shows good prognostic value in patients with hypopharyngeal squamous cell carcinoma undergoing pharyngectomy.
Why this matters
- The tool can help identify patients who will benefit from postoperative adjuvant treatment.
- Multivariate factors for poor survival included tumor size (HR, 1.479; P=.001), esophageal invasion (HR, 3.864; P=.000), extracapsular spread/internal jugular vein adhesion (HR, 2.475; P=.001), thyroid gland invasion (HR, 2.420; P=.027), and >3 lymph node metastases (HR, 2.208; P=.002).
- A nomogram based on these factors had a C-index value of 0.768 (95% CI, 0.719-0.817) in the development cohort and 0.767 (95% CI, 0.753-0.781) after bootstrapping for predicting OS.
- In stratified analysis based on nomogram score, postoperative adjuvant treatment:
- was associated with improved OS in high-risk patients (P=.0067),
- had no significant effect in moderate-risk patients (P=.3708), and
- reduced OS (P=.0249) in low-risk patients.
- 385 patients with primary hypopharyngeal SCC who received pharyngectomy, 187 who received postoperative adjuvant therapy, were included.
- Funding: Shanghai Shen-kang Hospital; Shanghai Municipality; National Natural Science Foundation of China; Shanghai Science and Technology Development Funds; Shanghai Municipal Health System; Shanghai Municipal Science and Technology Foundation.
- Retrospective study design.