Hypothyroidism linked to higher all-cause mortality in elders

  • Huang HK & al.
  • J Clin Endocrinol Metab
  • 26 Jun 2018

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A population-based study from Taiwan suggests that hypothyroidism is independently associated with all-cause mortality risk in patients ≥65 years old.

Why this matters

  • This study of >2000 patients adds to the evidence of a link between hypothyroidism and mortality risk.

Key results

  • Hypothyroidism was associated with increased risk for all-cause mortality in multivariate analysis (HR, 1.82; P<.001 style="list-style-type:circle;">
  • This result remained consistent in propensity score matching analysis (HR, 1.80; P<.001>
  • Patients with hypothyroidism also had increased risk for mortality because of cardiovascular disease (HR, 1.95; P<.001>
  • Patients with hypothyroidism who received thyroxine replacement therapy had reduced all-cause mortality risk (HR, 0.57; P<.001 and cardiovascular disease mortality risk compared with patients who did not.>

    Study design

    • 2029 patients with hypothyroidism aged ≥65 years and 20,290 matched control patients from the National Health Insurance Research Database of Taiwan were analyzed for risk for all-cause mortality and associated factors.
    • Funding: None.

    Limitations

    • Retrospective analysis of database information.
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