- Patients with IBD have high prevalence of osteopenia.
- A meta-analysis finds that patients with IBD are at increased risk for spine fractures but not overall fractures.
- Fractures were nonsignificantly more common in steroid users.
Why this matters
- Strict surveillance and prevention of spine fractures are advised for patients with IBD.
- Meta-analysis of 10 studies (n=470,541) that met eligibility criteria after search of PubMed/Medline, Google scholar, Scopus, EMBASE, and Cochrane database.
- Funding: None disclosed.
- No increased risk for overall fractures was seen in patients with IBD vs control patients (OR, 1.08; P=.70).
- There was no increase in risk for fractures of hip (P=.66), rib (P=1.00), and wrist (P=.97) vs control patients.
- Increased risk for spine fractures was seen in patients with IBD vs control patients (OR, 2.21; P<.0001>
- Steroid use was nonsignificantly more common among patients with IBD with fractures vs no fractures (OR, 1.47; P=.057).
- Osteoporosis was not more common among patients with IBD with fractures vs no fractures (OR, 1.60; P=.14).
- Variable power and outcomes among studies.