IBD linked to higher T2D risk

  • Jess T & al.
  • Clin Gastroenterol Hepatol
  • 5 Aug 2019

  • International Clinical Digest
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Takeaway

  • Patients with IBD show an increased long-term risk for type 2 diabetes (T2D) that is greatest during the first year after IBD diagnosis.

Why this matters

  • Patients with Crohn’s disease (CD) or ulcerative colitis (UC) may benefit from T2D screening.

Study design

  • Researchers analysed health data for a population-based cohort in Denmark (n=6,028,844; follow-up, 736,072 person-years), comparing the T2D status of patients with IBD to those without IBD and calculating standardised incidence ratios (SIRs) to assess T2D risk.
  • Funding: Novo Nordisk Foundation.

Key results

  • 3436 patients with IBD developed T2D vs 2224 expected cases: SIR, 1.54 (95% CI, 1.49-1.60).
  • T2D risk was highest during the first year after a diagnosis of IBD: SIR, 4.48 (95% CI, 4.16-4.83).
  • Risk persisted for 20 or more years after the diagnosis: SIR, 1.26 (95% CI, 1.16-1.38).

Limitations

  • Patient data did not include potential confounders, such as BMI or smoking status.

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