IBD linked to increased stroke, myocardial infarction risk

  • Choi YJ & al.
  • Aliment Pharmacol Ther
  • 8 Aug 2019

  • International Clinical Digest
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Takeaway

  • Crohn's disease (CD) and ulcerative colitis (UC) may confer a higher risk for myocardial infarction (MI) and stroke.

Why this matters

  • The association between IBD and cardiovascular disease is controversial, with previous studies reporting inconsistent results.

Study design

  • Researchers analysed the health records of patients diagnosed with CD or UC (N=37,477; 56.8% men; mean age, 40.4±16.6 years), comparing them with those of age-matched control patients.
  • Funding: National Research Foundation of Korea.

Key results

  • CD was associated with higher MI risk (HR, 1.80; 95% CI, 1.47‐2.21), especially among:
    • those aged
    • women (HR, 2.18; 95% CI, 1.61‐2.94).
  • Women with UC also had higher MI risk (HR, 1.33; 95% CI, 1.13‐1.56).
  • Patients aged
    • With CD: HR, 2.01 (95% CI, 1.11‐3.63).
    • With UC: HR, 1.86 (95% CI, 1.18‐2.95).

Limitations

  • Researchers did not adjust for the effects of IBD medication, statins, or aspirin.
  • Patients were participants in the South Korean universal health insurance system, and findings may not apply to other populations.

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