- Colonoscopic surveillance in patients with IBD is associated with a 42% reduction in colorectal cancer (CRC) risk, a higher rate of early-stage CRC diagnosis, and a 64% decrease in CRC-related death.
Why this matters
- The last meta-analysis of colonoscopic surveillance in IBD was conducted more than a decade ago, and found no association between surveillance and reduced CRC mortality.
- Meta-analysis of 5 studies with 7199 patients with ulcerative colitis or colonic Crohn’s disease.
- Funding: Cochrane Inflammatory Bowel Disease Group.
- Patients who did not undergo surveillance had a higher rate of CRC than those who did (3.2% vs 1.8%; (OR, 0.58; 95% CI, 0.42-0.80).
- Patients who underwent surveillance had significantly lower CRC mortality (8.5% vs 22.3%; OR, 0.36; 95% CI, 0.19-0.69) and higher rates of early-stage CRC detection (15.5% vs 7.7%; OR, 5.40; 95% CI, 1.51-19.30).
- Surveillance was associated with a lower risk for colectomy (36.3% vs 53.7%; OR, 0.49; 95% CI, 0.27-0.88), but that only included 1 study.
- No randomized clinical trials were included.