- Patients with IBD are almost twice as likely as those without IBD to be diagnosed with Parkinson's disease (PD).
- Treatment with corticosteroids or anti-TNF agents appears to cut this risk.
Why this matters
- Although the reason for this association is unknown, patients with Crohn’s disease (CD) or ulcerative colitis (UC) should be aware of the potential risk for comorbid PD.
- Researchers analysed the health records of patients with CD (n=12,631) or UC (n=26,230; total cohort mean age, 39.91±16.62 years; 61.2% men), comparing them with those of age- and sex-matched control patients.
- Funding: None disclosed.
- PD risk for patients with IBD was significantly higher, even when adjusted for health care use: adjusted [a]HR, 1.87 (P<.001>
- PD risk was particularly high with CD: aHR, 2.23 (P=.023).
- With UC, risk was increased but not as steeply: aHR, 1.85 (P<.001>
- Patients with CD were less likely to develop PD when treated with corticosteroids: aHR, 0.08 (P<.001>
- No patients with IBD treated with anti-TNF agents (n=2110) experienced PD during 9950 person-years.
- Patients were participants in the South Korean universal health insurance system; findings may not apply to other populations.
- Data on genetic risk factors for PD were not available.