IBD tied to bipolar disorder in nationwide cross-sectional study

  • Kao LT & al.
  • J Affect Disord
  • 15 Jan 2019

  • curated by Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • Inflammatory bowel disease (IBD) is associated with a ~2-fold excess risk for bipolar disorder (BD), according to data from a population-based cross-sectional study.
  • Subgroup analysis finds excess risk restricted to ulcerative colitis (UC), not Crohn's disease (CD).

Why this matters

  • IBD and BD appear to share some biological pathways, according to experimental studies.
  • This study, the largest to date, may help resolve previously conflicting human studies.

Study design

  • Cross-sectional cohort of 3590 patients with IBD and 14,360 propensity-matched (on age, sex, monthly income, among others) non-IBD control patients from the Taiwan National Health Insurance Research Database.
  • Funding: None.

Key results

  • BD occurred in 0.72% of people with IBD and 0.34% of people without IBD.
  • IBD is associated with a more than 2-fold increased risk for BD (aOR, 2.10; 95% CI, 1.30∼3.38).
    • In subgroup analysis, UC is associated with increased risk for BD (aOR, 2.23; 95% CI, 1.31∼3.82).
    • CD is not associated with increased risk for BD.

Limitations

  • Cross-sectional, observational design cannot establish causality.
  • Lifestyle factors (eg, BMI, alcohol, smoking) not captured.
  • Reliance on insurance database.

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