- Inflammatory bowel disease (IBD) is associated with a ~2-fold excess risk for bipolar disorder (BD), according to data from a population-based cross-sectional study.
- Subgroup analysis finds excess risk restricted to ulcerative colitis (UC), not Crohn's disease (CD).
Why this matters
- IBD and BD appear to share some biological pathways, according to experimental studies.
- This study, the largest to date, may help resolve previously conflicting human studies.
- Cross-sectional cohort of 3590 patients with IBD and 14,360 propensity-matched (on age, sex, monthly income, among others) non-IBD control patients from the Taiwan National Health Insurance Research Database.
- Funding: None.
- BD occurred in 0.72% of people with IBD and 0.34% of people without IBD.
- IBD is associated with a more than 2-fold increased risk for BD (aOR, 2.10; 95% CI, 1.30∼3.38).
- In subgroup analysis, UC is associated with increased risk for BD (aOR, 2.23; 95% CI, 1.31∼3.82).
- CD is not associated with increased risk for BD.
- Cross-sectional, observational design cannot establish causality.
- Lifestyle factors (eg, BMI, alcohol, smoking) not captured.
- Reliance on insurance database.