IBD with CRC: 1 in 8 develops cancer before the recommended screening period

  • Dig Dis Sci

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • 1 in 8 patients with IBD developed colorectal cancer (CRC) before the currently recommended period for initiating CRC screening in this population.
  • Factors predicting early CRC include IBD onset before age 28 years and tobacco use.

Why this matters

  • Recommendations are for CRC surveillance at 8-10 years after IBD onset.

Key results

  • Average time to CRC diagnosis after IBD onset was 22.8 (standard deviation [SD], 12.5) years. 
  • 11.8% developed CRC before the 8-year mark after IBD onset (mean, 3.5 years; SD, 3.0 years).
  • 12.8% of those under age 50 years were diagnosed with CRC in
  • Risk factors for CRC
    • Age >28 years: 12.0 (2.30-62.75).
    • Tobacco use: 8.52 (1.38-52.82).

Study design

  • Single-center, observational study, 93 patients with IBD and diagnosed with CRC.
  • Those with earlier vs later CRC diagnoses were compared.
  • Funding: NIH.

Limitations

  • Retrospective, observational, single tertiary-care center.

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