IBS is linked to elevated risk for COPD

  • Lai HC & al.
  • Sci Rep
  • 19 Jun 2020

  • curated by Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • Irritable bowel syndrome (IBS) is tied to a 51% increased risk of developing COPD, especially if untreated.
  • The relationship likely related to shared infection, inflammation, and microbiota factors.

Why this matters

  • Clinicians may consider monitoring patients with IBS for COPD and aggressive treatment for the IBS.

Study design

  • Population-based study using the Taiwan National Health Insurance system of patients diagnosed with IBS between 2000 and 2011 with follow-up for ≥1 year.
  • Cumulative incidence of COPD was compared among patients with IBS (n=14,021) and unaffected, propensity-matched control individuals (n=42,068).
  • Funding: Ministry of Science and Technology, Taiwan.

Key results

  • IBS was associated with an increased risk for COPD (adjusted HR, 1.512; P<.0001>
  • Finding was consistent across all age groups and sexes.
  • Receipt of IBS medication for >28 days vs
  • IBS medications included steroids, anti-cholinergics, and β2 agonists.
  • Having >18 clinical visits vs

    Limitations

    • Observational.