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Clinical Summary

IBS risk is doubled with asthma and vice versa

Takeaway

  • In patients with irritable bowel syndrome (IBS), risk for asthma is doubled, and the reverse is also true, according to the results of this meta-analysis.

Why this matters

  • Clinicians should be alert to the potential for the 2 conditions to co-occur.

Key results

  • In people with asthma, the risk for IBS is doubled: pooled OR, 2.0 (95% CI, 1.5-2.8).
    • 7 studies (5 case-control, 2 cohort), n=30,569 with asthma and 119,484 unaffected; I2=69.5% (P=.03).
  • The reverse is also the case, and asthma risk is elevated with IBS: pooled OR, 2.2 (95% CI, 1.3-3.9).
    • 4 studies, n=30,415 with IBS and 124,107 unaffected; I2=81.3% (P=.001).

Study design

  • Meta-analysis and review of 10 studies.
  • Funding: None disclosed.

Limitations

  • Most studies did not classify by disease severity.

References


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