- Among patients with irritable bowel syndrome (IBS), a starch- and sucrose-reduced diet (SSRD) leads to rapid symptomatic improvement.
Why this matters
- Many patients with IBS do not respond to the usual dietary suggestions, such as a low FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) diet.
- IBS has been linked to higher prevalence of pathogenic sucrase-isomaltase gene variants.
- SSRD was developed to treat congenital sucrase-isomaltase deficiency.
- Randomized 2-week trial (n=105).
- Adults with symptomatic IBS were randomly assigned to SSRD (avoiding sucrose and reducing refined cereal intake) vs usual diet.
- Outcomes: changes in IBS-symptom severity scale (IBS-SSS), visual analog scale for IBS (VAS-IBS).
- Funding: Swedish nonprofits.
- SSRD group’s improved outcomes after intervention vs baseline (all P<.001 ibs-sss vas-ibs abdominal pain diarrhea constipation bloating and flatulence psychological well-being.>
- Above outcomes did not change vs baseline in the usual-diet group.
- SSRD vs usual-diet group, >50% reduction in IBS-SSS score: 31.1% vs 0% (P<.001>
- Reduced cereal intake correlated significantly with lower IBS-SSS and less abdominal pain and diarrhea.
- Reduced sweets/soft drinks intake correlated significantly with lower IBS-SSS and less abdominal pain, diarrhea, bloating, and flatulence.
- Improvement noted within 2-3 days.
- Small, brief trial.
- All participants were Northern European.