Ibuprofen: no postpartum BP bump in mild hypertensive disorders of pregnancy

  • Penfield CA & al.
  • Obstet Gynecol
  • 4 Nov 2019

  • International Clinical Digest
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Takeaway

  • Ibuprofen, an NSAID, did not increase postpartum BP in women with mild hypertensive disorder of pregnancy.

Why this matters

  • NSAIDs have been found to raise BP in adults with chronic hypertension.
  • Some have recommended avoiding NSAIDs in the postpartum period in women with hypertensive disorders despite them being good pain relievers and reducing the need for opioids.

Key results

  • There was no difference in average postpartum mean arterial BP between the ibuprofen and the control groups.

Study design

  • Double-blind, randomised controlled trial between 2017 and 2018.
  • The cohort was taken from the Hypertension in Postpartum Preeclampsia Study.
  • The participants had a hypertensive disorder of pregnancy without severe features.
  • Women were randomly assigned to receive ibuprofen (n=31) vs controls (n=30).
  • The primary outcome was the average of each participant's mean BP measurements during the postpartum hospital stay.
  • Funding: The MemorialCare Medical Center Foundation.

Limitations

  • Small numbers in the study.
  • Women with severe hypertension were excluded.