- Pediatric COVID-19 fatalities in Europe have been lower than in older adults, but some children develop severe illness requiring prolonged ICU support.
Why this matters
- Most pediatric patients requiring COVID-19-associated intubation will need prolonged support.
- 582 confirmed cases, 77 institutions, 21 countries.
- Median age, 5.0 (interquartile range [IQR], 0.5-5.12) years; range, 3 days-18 years.
- 62% admitted to the hospital, 13% to ICU.
- 5% had chronic pulmonary disease, 5% malignancy, 4% neurological disorders, 4% congenital heart disease, 2% chromosomal abnormality, 2% chronic kidney disease.
- 13% required oxygen, 5% continuous positive airway pressure (CPAP), and 4% mechanical ventilation (MV).
- Median MV duration: 7 (IQR, 2-11; range, 1-34) days.
- ICU admission risk factors (ORs) on multivariate analysis:
- Younger age (
- Male sex: 2.12 (P=.033).
- Lower respiratory tract infection at presentation: 10.46 (P<.0001>
- Preexisting medical condition: 3.27 (P=.0015).
- Treatment: hydroxychloroquine (7%), remdesivir (3%), lopinavir-ritonavir (1%), oseltamivir (1%)
- Case fatality rate: 0.69% (4 children; 95% CI, 0.20%-1.82%).
- Multinational, multicenter cohort study.
- Funding: None disclosed.
- Laboratory, ICU variables not collected.
- Multiple in-house/commercial assays.
- Small treatment group.