- Women with idiopathic intracranial hypertension (IIH) had more than twice the risk of cardiovascular events compared with those without IIH.
Why this matters
- Findings suggest a change in clinical practice that includes assessment and management of cardiovascular disease (CVD) risk factors in IIH may reduce long-term morbidity.
- This population-based matched controlled study used data from The Health Improvement Network.
- 2769 female patients with IIH and randomly matched 27,125 control individuals by body mass index and age were included.
- Primary outcomes: composite of any CVD (heart failure, ischaemic heart disease, and stroke).
- Secondary outcomes: CVD outcome, type 2 diabetes, and hypertension.
- Funding: None disclosed.
- Median follow-up was 3.5 years.
- Women with IIH vs those without had significantly higher risks for cardiovascular outcomes:
- Compound CVD: adjusted HR (aHR), 2.10; 95% CI, 1.61-2.74; P<.001>
- Heart failure: aHR, 1.97; 95% CI, 1.16-3.37; P=.01;
- Ischaemic heart disease: aHR, 1.94; 95% CI, 1.27-2.94; P=.002;
- Stroke/transient ischaemic attack: aHR, 2.27; 95% CI, 1.61-3.21; P<.001>
- Type 2 diabetes: aHR, 1.30; 95% CI, 1.07-1.57; P=.009; and
- Hypertension: aHR, 1.55; 95% CI, 1.30-1.84; P<.001.>
- Risk for bias.