- Rapid identification of central nervous system (CNS) pathogens with BioFire Meningitis Enchephalitis PCR assay can help prevent repeat lumbar punctures (LP).
Why this matters
- Patients admitted to a hospital with symptoms of meningitis or encephalitis are at risk for adverse clinical outcomes.
- Faster diagnosis and confirmation of CNS organisms can prevent repeat LP and decrease unnecessary antimicrobial therapies.
- Retrospective review initiated by clinical staff.
- Cerebrospinal fluid (CSF) samples were obtained from the microbiology laboratory from patients who had been admitted with symptoms of meningitis or encephalitis.
- Testing was performed on CSF specimens that had not been centrifuged via BioFire FilmArray Meningitis Encephalitis PCR assay.
- Funding: None.
- Pediatric and adult patients were included for analysis (27.1% and 72.8%).
- Repeat LP required: 21.4%.
- Median time to repeat LP: 4 days.
- Median time to BioFire organism diagnosis: 26 hours.
- Patients with negative BioFire were often prescribed antiviral and antibiotic therapy (47.8% and 97.8%).
- BioFire identified a pathogen in 33.3% of patients with a discharge diagnosis of unknown etiology using conventional methods.
- Single-center review.
- Results presented at a conference and not peer-reviewed.