Impact of bariatric surgery on long-term cardiovascular outcomes

  • Moussa O & al.
  • Eur Heart J
  • 19 Mar 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Bariatric surgery is associated with lower long-term risk for major cardiovascular events, incident heart failure, and mortality in patients with obesity.

Why this matters

  • Bariatric surgery may be an effective means of improving long-term cardiovascular outcomes of patients with obesity.

Study design

  • A nested cohort study included 3701 obese patients who underwent bariatric surgery and 3701 matched controls using data from the UK Clinical Practice Research Datalink (CPRD).
  • Primary outcome: major cardiovascular events (fatal or non-fatal myocardial infarction and ischaemic stroke).
  • Funding: National Institute for Health Research Imperial Biomedical Research Centre.

Key results

  • Bariatric surgery vs control group had a significantly lower risk for major cardiovascular events (HR, 0.410, 95% CI, 0.274-0.615; P<.001>
  • This was mainly driven by a reduction in myocardial infarction (HR, 0.412; 95% CI, 0.280-0.606; P<.001 and not acute ischaemic stroke ci p=".301).</li">
  • The risk for incident heart failure (HR, 0.403; 95% CI, 0.181-0.897; P=.026) and all-cause mortality (HR, 0.254; 95% CI, 0.183-0.353; P<.001 was lower in bariatric surgery vs control group.>

Limitations

  • Retrospective design.
  • Lack of access to causes of mortality.