Impact of Chlamydia on pregnancy and fertility-related outcomes

  • Tang W & al.
  • Sex Transm Infect
  • 13 Dec 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Chlamydia trachomatis was associated with an increased risk for several pregnancy and fertility-related adverse outcomes.

Why this matters

  • Chlamydia trachomatis is the most common bacterial sexually transmitted infection in the world.
  • Limited studies have confirmed the relationship between chlamydia infection and pregnancy and fertility-related adverse outcomes.

Study design

  • The meta-analysis of 107 studies reporting pregnancy and fertility outcomes associated with chlamydia infection.
  • Funding: National Institutes of Health.

Key results

  • Chlamydia infection was positively associated with pregnancy and fertility-related adverse outcomes, including:
    • stillbirth (OR, 5.05; 95% CI, 2.95-8.65 for case-control studies and risk ratio [RR], 1.28; 95% CI, 1.09-1.51 for cohort studies) and
    • spontaneous abortion (OR, 1.30; 95% CI, 1.14-1.49 for case-control studies and RR, 1.47; 95% CI, 1.16-1.85 for cohort studies).
  • The risk for chlamydia infection was higher among women with infertility vs those without (pooled OR, 2.72; 95% CI, 2.37-3.12 for case-control studies and RR, 1.84; 95% CI, 1.77-1.90).
  • Compared with high-income countries, the risk for adverse outcomes was associated with chlamydia infection is higher in low- and middle-income countries.

Limitations

  • Heterogeneity across studies.