Takeaway
- Among people with prediabetes, lung function can already be impaired, according to findings from this cross-sectional study.
Why this matters
- Evidence is mounting that diabetes adversely affects the lung.
- Lower FEV1 has been linked to higher mortality in the general population and in those with type 2 diabetes.
- In 2011-2012, 38.0% of the US general population was prediabetic.
Key results
- FVC:
- 93% with prediabetes (interquartile range [IQR], 82%-105%) vs
- 96% without (IQR, 84%-106%; P<.001).
- FEV1:
- 94% with prediabetes (IQR, 82%-107%) vs
- 96% without (IQR, 84%-108%); P=.009.
- Restrictive spirometry pattern in:
- 16.5% with prediabetes vs
- 13.7% without (P=.013).
- FEV1 <80% in:
- 20.3% with prediabetes vs
- 17.3% without (P=.017).
- On multivariate analysis, higher HbA1c correlated with:
- Restrictive spirometry: OR, 1.42 (95% CI, 1.10-1.83; P=.008); and
- FEV1 <80%: OR, 1.50 (95% CI, 1.19-1.90; P=.001).
Study design
- Analysis of respiratory function, prediabetes parameters in middle-aged participants in the cross-sectional ILERVAS study (n=4459).
- No participant had diagnosis of diabetes, cardiovascular disease, or COPD.
- Outcome: associations between prediabetes and pulmonary function.
- Funding: Lleida Provincial Council, Autonomous Government of Catalonia.
Limitations
- Patients were Spaniards; results might not generalize to other populations.
- Causal relationship not established.
References
References