- In a small retrospective analysis, surgery is associated with better survival rates than no surgery in elderly patients with pancreatic cancer.
Why this matters
- Elderly patients have traditionally not undergone surgery because of fears of complications, but recent studies showed no difference in 90-day mortality or severe morbidity among elderly patients.
- Retrospective analysis of records from the National Cancer Center in Korea (n=49; age, ≥75 years; 38 surgery; 11 no surgery).
- Funding: None.
- Surgeries: Whipple's operation (6 surgeries), pylorus-preserving pancreaticoduodenectomy (16 surgeries), total pancreatectomy (4 surgeries), distal pancreatectomy (12 surgeries).
- No surgery group: 3 could not undergo surgery because of poor health, 8 declined surgery or other treatment.
- The surgery group had a higher median survival time after diagnosis (17±5.5 vs 10±2.8 months).
- A univariate analysis showed not undergoing surgical resection to be a risk factor for OS (HR, 2.412; P=.022), along with a high Charlson comorbidity index (HR, 5.252; P=.014).
- 2-year survival was 40.7% in the surgery group and 0% in the no-surgery group (P=.015).
- Median survival was higher in the surgery group: 22 vs 14 months.
- 31.6% had C-D classification III/IV postoperative complications.
- Retrospective analysis.
- Korean population.