In prolonged spondyloarthritis, diverticulitis is something to watch for

  • Derakhshan MH & al.
  • J Clin Med
  • 26 Feb 2019

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • In patients with spondyloarthritis (SpA), the risk for diverticulitis is increased as duration of SpA progresses.
  • Risk is seen especially with axial disease.

Why this matters

  • Both conditions involve inflammation, which the authors speculate is the tie that binds them.

Key results

  • SpA was not associated with gastrointestinal ulcers or viral hepatitis.
  • Longer SpA duration was linked to increased odds for diverticulitis:
    • OR, 1.18 (95% CI, 1.03-1.34) for every 5 years of SpA.
  • Axial SpA showed the strongest association:
    • OR, 1.23 (95% CI, 1.06-1.43; P=.006).
  • Older age (P<.001>), alcohol intake (≥3 units/day; P=.005) also were tied to increased diverticulitis risk.
  • No link seen with BMI, medication history, ever-diagnosis of IBD.

Study design

  • International, cross-sectional ASAS-COMOSPA study, 3872 participants.
  • Data adjusted for BMI, medication, sex, etc.
  • Estimated median SpA disease duration: 5.1 (interquartile range, 1.3-11.8) years.
  • Funding: Abbvie, Pfizer, others.

Limitations

  • Questionnaire-based data.
  • Subject to the limitations of cross-sectional designs.

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