- In patients with spondyloarthritis (SpA), the risk for diverticulitis is increased as duration of SpA progresses.
- Risk is seen especially with axial disease.
Why this matters
- Both conditions involve inflammation, which the authors speculate is the tie that binds them.
- SpA was not associated with gastrointestinal ulcers or viral hepatitis.
- Longer SpA duration was linked to increased odds for diverticulitis:
- OR, 1.18 (95% CI, 1.03-1.34) for every 5 years of SpA.
- Axial SpA showed the strongest association:
- OR, 1.23 (95% CI, 1.06-1.43; P=.006).
- Older age (P<.001>), alcohol intake (≥3 units/day; P=.005) also were tied to increased diverticulitis risk.
- No link seen with BMI, medication history, ever-diagnosis of IBD.
- International, cross-sectional ASAS-COMOSPA study, 3872 participants.
- Data adjusted for BMI, medication, sex, etc.
- Estimated median SpA disease duration: 5.1 (interquartile range, 1.3-11.8) years.
- Funding: Abbvie, Pfizer, others.
- Questionnaire-based data.
- Subject to the limitations of cross-sectional designs.