- Bumping the daily increment increase for milk feeding from 18 to 30 mL/kg in preterm infants born
- Randomized controlled trial findings show no effects on infectious outcomes or death, either.
Why this matters
- Some observational results had suggested an association of enteral feeding volume advance on risk for necrotizing enterocolitis and late-onset sepsis.
- 1224 infants experienced the faster advance (30 mL/kg/day), and 1246 experienced the slower increment (18 mL/kg/day).
- Survival without moderate-severe neurodevelopmental disability at age 2 years was 65.5% with the faster increment vs 68.1% with the slower approach.
- Adjusted risk ratio (aRR): 0.96 (95% CI, 0.92-1.01).
- Late-onset sepsis rate was 29.8% with faster increment vs 31.1% with slower (aRR, 0.96; 95% CI, 0.86-1.07).
- Necrotizing enterocolitis rate was 5.0% in the faster group vs 5.6% in the slower group (aRR, 0.88; 95% CI, 0.68-1.16).
- Mortality at age 2 years was 5.6% with the faster increment vs 6.2% with the slower.
- Infants were randomly allocated to 1 of the feeding protocols, from June 8, 2013 to June 30, 2015, at 55 hospitals.
- Funding: National Institute for Health Research.
- Trial was not blinded.