- 4 clinical risk factors can help identify patients with a lesion that is indefinite for neoplasm/dysplasia (IFND) who could benefit from endoscopic resection, rather than repeated endoscopic biopsy.
- 2 or more clinical risk factors should be considered for resection, and diagnosis should be made within 1 year for patients without risk factors.
Why this matters
- There is limited guidance for how to follow-up and monitor patients with IFND.
- Retrospective analysis of 461 patients with IFND at a single institution in Korea whose diagnoses were confirmed by endoscopic resection (n=134), surgery (n=22), or follow-up endoscopic biopsy (n=305).
- Funding: None disclosed.
- Multivariate analysis revealed 6 factors associated with increased risk for gastric carcinoma:
- Age ≥60 years (OR, 2.445; P=.005).
- Endoscopic size ≥10 mm (OR, 3.519; P<.001>
- Single lesion (OR, 5.702; P<.001>
- Spontaneous bleeding (OR, 4.056; P=.001).
- Atypical epithelium described as IFND (OR, 25.575; P<.001>
- Repeated pathologic reports of IFND (OR, 6.022; P=.003).
- Retrospective analysis.