- Probiotic exposure during the first year of life does not appear to reduce risk for celiac disease (CD) autoimmunity or CD in children genetically predisposed to type 1 diabetes (T1D) and CD.
- Exposure from dietary supplements alone is linked to a slight increase in CD risk.
Why this matters
- Giving probiotics to healthy infants is considered safe and is assumed to have a positive effect on regulation of the immune system.
- Researchers studied children (N=6520) with the human leukocyte antigen genotypes DR3/3, DR3/4, DR4/4, and DR4/8 and screened for tissue transglutaminase autoantibodies and reported probiotic use during the first year of life.
- Funding: NIH; CDC.
- After adjustment for known risk factors, probiotic exposure in the first year of life was not linked to:
- CD autoimmunity: HR, 1.15 (95% CI, 0.99-1.35; P=.07); or
- CD: HR, 1.11 (95% CI, 0.86-1.43; P=.43).
- Exposure to probiotic dietary supplements alone, however, was associated with a slightly increased risk for CD autoimmunity: HR, 1.18 (95% CI, 1.01-1.40; P=.043).
- Probiotics dose could not be studied because information was unavailable on their manufacture and storage.
- Study participants were exposed to a large variety of probiotic supplements and infant formulas.