- Long-acting gonadotropin-releasing hormone agonist (GnRH-a) is associated with increased serum levels of thyroid-stimulating hormone (TSH) in women with infertility undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).
Why this matters
- The relationship between TSH levels and IVF/ICSI outcomes in infertile patients is controversial.
- Overall, GnRH-a was associated with increased serum TSH levels (P<.05>
- 63.3% of patients had elevated serum TSH, and 9.7% experienced subclinical hypothyroidism (TSH>4.5 mIU/L).
- In patients with basal serum TSH >0.35 mIU/L and
- In patients with basal serum TSH ≥2.5 mIU/L and
- Patients with basal serum TSH >0.35 mIU/L and
- 207 patients with infertility and euthyroid status (no history of hypothyroidism and normal TSH levels) scheduled for IVF/ICSI were injected with long-acting GnRH-a and analyzed for outcomes.
- Funding: None disclosed.
- Small patient sample size in respective subgroups.