Infertility: ovarian stimulation with GnRH-a raises TSH levels

  • Eur J Obstet Gynecol Reprod Biol

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Long-acting gonadotropin-releasing hormone agonist (GnRH-a) is associated with increased serum levels of thyroid-stimulating hormone (TSH) in women with infertility undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).

Why this matters

  • The relationship between TSH levels and IVF/ICSI outcomes in infertile patients is controversial.

Key results

  • Overall, GnRH-a was associated with increased serum TSH levels (P<.05>
  • 63.3% of patients had elevated serum TSH, and 9.7% experienced subclinical hypothyroidism (TSH>4.5 mIU/L).
  • In patients with basal serum TSH >0.35 mIU/L and
  • In patients with basal serum TSH ≥2.5 mIU/L and
  • Patients with basal serum TSH >0.35 mIU/L and

Study design

  • 207 patients with infertility and euthyroid status (no history of hypothyroidism and normal TSH levels) scheduled for IVF/ICSI were injected with long-acting GnRH-a and analyzed for outcomes.
  • Funding: None disclosed.

Limitations

  • Small patient sample size in respective subgroups.

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