- Meta-analysis suggests high levels of inflammation markers, C-reactive protein (CRP), high-sensitive CRP (hs-CRP), interleukin-6 are associated with significant risk of developing hypertension.
Why this matters
- Further research is warranted to evaluate these inflammatory markers as a screening tool to identify individuals at high risk of hypertension.
- Meta-analysis of 14 studies including 142,640 participants and 20,676 patients with incident hypertension identified after a search on PubMed and Scopus until July 2018.
- Association of inflammatory markers (CRP, hs-CRP, interleukin-6 and interleukin-1β) with risk for hypertension was calculated for the third vs first tertiles of the inflammation markers.
- Funding: None declared.
- Higher levels of CRP showed significant association with the risk for hypertension (12 studies; relative [RR], 1.17; 95% CI, 1.12-1.22).
- For CRP, the association was significantly stronger in women (RR, 1.25; 95% CI, 1.06-1.44) than in men (RR, 1.10; 95% CI, 1.03-1.16).
- Increase in hs-CRP significantly increased the risk for hypertension (7 studies; RR, 1.06; 95% CI, 1.01-1.07).
- Increase in interleukin-6 levels was associated with higher risk for hypertension (5 studies; RR 1.51; 95% CI, 1.30-1.71).
- Interleukin-β showed no association with risk of developing hypertension.
- Observational studies were included.