Inflammation markers tied to hypertension risk

  • Jayedi A & al.
  • Heart
  • 30 Jan 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Meta-analysis suggests high levels of inflammation markers, C-reactive protein (CRP), high-sensitive CRP (hs-CRP), interleukin-6 are associated with significant risk of developing hypertension.

Why this matters

  • Further research is warranted to evaluate these inflammatory markers as a screening tool to identify individuals at high risk of hypertension.

Study design

  • Meta-analysis of 14 studies including 142,640 participants and 20,676 patients with incident hypertension identified after a search on PubMed and Scopus until July 2018.
  • Association of inflammatory markers (CRP, hs-CRP, interleukin-6 and interleukin-1β) with risk for hypertension was calculated for the third vs first tertiles of the inflammation markers.
  • Funding: None declared.

Key results

  • Higher levels of CRP showed significant association with the risk for hypertension (12 studies; relative [RR], 1.17; 95% CI, 1.12-1.22).
  • For CRP, the association was significantly stronger in women (RR, 1.25; 95% CI, 1.06-1.44) than in men (RR, 1.10; 95% CI, 1.03-1.16).
  • Increase in hs-CRP significantly increased the risk for hypertension (7 studies; RR, 1.06; 95% CI, 1.01-1.07).
  • Increase in interleukin-6 levels was associated with higher risk for hypertension (5 studies; RR 1.51; 95% CI, 1.30-1.71).
  • Interleukin-β showed no association with risk of developing hypertension.

Limitations

  • Observational studies were included.

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