Influenza: is live attenuated vaccine safe in children with underlying conditions?
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No increased risk for all-cause hospitalization after live attenuated influenza vaccine (LAIV) receipt among children with nonasthma, nonimmunocompromising underlying medical conditions compared with healthy children.
Why this matters
Original clinical trials for LAIV excluded children with underlying conditions, but these findings support its safety in children with nonasthma, nonimmunocompromising conditions.
MarketScan Commercial Claims Databases used to identify children aged 2-18 y who received LAIV (2010-2012), including those with underlying medical conditions.
Primary outcome: all-cause hospitalization within 14 d of vaccination.
Funding: Centers for Disease Control and Prevention.
1,216,123 children vaccinated, 99,208 with underlying medical condit...