- No increased risk for all-cause hospitalization after live attenuated influenza vaccine (LAIV) receipt among children with nonasthma, nonimmunocompromising underlying medical conditions compared with healthy children.
Why this matters
- Original clinical trials for LAIV excluded children with underlying conditions, but these findings support its safety in children with nonasthma, nonimmunocompromising conditions.
- MarketScan Commercial Claims Databases used to identify children aged 2-18 y who received LAIV (2010-2012), including those with underlying medical conditions.
- Primary outcome: all-cause hospitalization within 14 d of vaccination.
- Funding: Centers for Disease Control and Prevention.
- 1,216,123 children vaccinated, 99,208 with underlying medical conditions (excluding asthma, hemoglobinopathies, malignancy, pregnancy, HIV/AIDS, and non-HIV immunodeficiencies).
- 642 hospitalizations within observation period.
- Pneumonia and acute appendicitis most common reasons for hospitalization (10.4% and 5.9%, respectively).
- No increased risk for hospitalization among children with and without underlying medical conditions.
- Included only commercially insured children.
- Limited to database information, no chart reviews.
- No evaluation of medically attended events not requiring hospitalization.