Influenza vaccination: how does timing influence effectiveness?

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  • Waning protection with time since influenza vaccination most pronounced among patients with prior season vaccination.

Why this matters

  • Careful consideration of risks and benefits of delayed vaccination needed before changes to current vaccine recommendations.

Study design

  • US Influenza Vaccine Effectiveness Network.
  • Pooled data from 2011-12 through 2014-15 seasons.
  • Patients ≥9 y old with laboratory-confirmed influenza.
  • Considered vaccinated if dosed at least 14 d before illness onset.
  • Funding: US Centers for Disease Control and Prevention.

Key results

  • Vaccine effectiveness (VE) against influenza A(H3N2) (n=11,200),  influenza A(H1N1)pdm09 (n=4100), and influenza B (n=5525).
  • Adjusted VE decreased with increasing time since vaccination for influenza A(H3N2) (P=.004), i...