- Inpatient hypoglycemia is an independent risk factor for amputations in patients with diabetic foot ulcers (DFUs).
- In-hospital hypoglycemia should be minimized.
Why this matters
- An estimated 50%-70% of lower extremity amputations are preceded by a DFU.
- DFUs are associated with significant financial burden, impaired QoL, and reduced life expectancy.
- Retrospective cohort study including 418 patients hospitalized for DFUs during 2015-2017.
- Hyperglycemia: ≥3 blood glucose measurements of ≥250 mg/dL (13.9 mmol/L).
- Severe hyperglycemia: ≥3 of ≥350 mg/dL (19.4 mmol/L).
- Hypoglycemia: ≥1 measurement of
- Severe hypoglycemia: ≥1 of
- Funding: None.
- During hospitalization:
- 73% experienced any hyperglycemia, including 30% with severe hyperglycemia.
- 48% experienced any hypoglycemia, including 22% with severe hypoglycemia.
- 55% underwent amputation, including major amputation in 47%.
- 58.70% with inpatient hyperglycemia vs 21.80% without (P<.05>
- 66.20% with hypoglycemia vs 44.20% without (P<.001>
- 28.50% with inpatient hyperglycemia vs 18.60% without (P<.05>
- 35.30% with hypoglycemia vs 17.10% without (P<.001>
- Retrospective, observational study.
- HbA1c measurements unavailable.