- An inpatient opioid prescribing protocol that prioritized oral and subcutaneous opioid administration over intravenous (IV) administration reduced the use of IV opioids by 84% and the overall use of oral or parenteral opioids by 23%.
Why this matters
- Compared with orally administered opioids, IV-administered opioids increase the risk for adverse events, including euphoria, nausea, and hypotension.
- Pilot study of 414 attending physicians, nurse practitioners, and physician assistants (intervention group, n=127; control, n=287) who prescribed opioids.
- Reduction in IV opioid doses administered per patient-day and total parenteral and overall opioid doses per patient-day and exposure were assessed.
- Funding: None disclosed.
- Mean age of the participants was 57.6 years; the control period included 4500 patient-days and intervention period included 2459 patient-days.
- During the intervention period, significant reduction observed in IV opioid doses (84%; P<.001 and combined doses of parenteral opioids administered either intravenously or subcutaneously p>
- In the intervention group, mean daily parenteral opioid exposure decreased by 49% and rate of parenteral opioid administration decreased by 57% (P<.001>
- Significant reduction in opioid dose administered by oral or parenteral route (23%; P=.02) and in mean daily overall opioid exposure (31%).
- Single-center study.
Coauthored with Anand Ramanathan, PharmD