- For children born following conception through assisted reproductive technology (ART), intellectual disability (ID) risk is slightly increased.
- Greater increases seen with very preterm birth or intracytoplasmic sperm injection (ICSI).
Why this matters
- Accompanying editorial notes some limitations on data quality , including variability in care access, follow-up services, and type of practitioner involved.
- The risk ratio (RR) for ID among children conceived via ART was 1.58 (95% CI, 1.19-2.11).
- RR increase seen even with singleton births: 1.56 (1.10-2.21).
- RR for ID was highest with ICSI: 2.54 (1.69-3.83).
- For mild-moderate ID, with ART, RR was 1.51 (95% CI, 1.11-2.06).
- For severe ID, RR was 2.55 (1.19-5.44).
- ART-conceived children had older mothers, were more likely to be twins, be born preterm, and have a major birth defect.
- Down syndrome accounted for 1 in 10 cases involving ID among ART-conceived children.
- Data from population-based registers, Australia, for live births, 1994-2002 (n=210,627), ≥8 years of follow-up.
- ID prevalence compared between ART- (1.4% of cohort; n=2876) and non-ART-conceived (207,751) children, risk-assessed.
- Funding: National Health and Medical Research Council; Ferring Pharmaceuticals.
- No adjustment for multiple comparisons.
- Some CIs close to unity.
- Some relevant maternal factors (e.g., obesity) not available.