- Intensive BP control did not reduce dementia incidence but mitigated incident mild cognitive impairment (MCI) in this analysis from the Systolic Blood Pressure Intervention Trial ( SPRINT ).
- The authors say a longer follow-up in this SPRINT Memory and Cognition in Decreased Hypertension (MIND) study might uncover a link to dementia as well.
Why this matters
- Hypertension might be a modifiable factor linked to dementia risk, although some studies have linked low BP with increased risk for cognitive impairment.
- Editorial: a limitation is that SPRINT excluded people with common conditions of aging, including diabetes, stroke, and heart failure.
- Probable dementia diagnoses:
- Intensive treatment: 7.2/1000 person-years vs
- Standard treatment: 8.6/1000 person-years;
- HR, 0.83 (95% CI, 0.67-1.04; not significant).
- Intensive treatment: 14.6/1000 person-years vs
- Standard treatment: 18.3/1000 person-years;
- HR, 0.81 (95% CI, 0.69-0.95).
- Controlling for extended follow-up suggested that with longer follow-up, more cases of dementia/MCI would be identified, with results favoring intensive treatment.
- Data for 9361 SPRINT participants analyzed (mean age, 67.9 [standard deviation, 9.4] years).
- Intensive treatment (systolic BP
- Outcomes: probable dementia, MCI, composite of both.
- Funding: NIH; others.
- MCI prevalence at baseline not known.